Adrenergic Receptors in Rat Liver

Liver cell adenylate cyclase and beta-adrenergic receptors. Increased beta-adrenergic receptor number and responsiveness in the hypothyroid rat.

@Adrenergic stimulation of adenylate cyclase activity and 8-adrenergic receptor status were assessed in whole homogenates and various subcellular fractions of isolated hepatocytes obtained from hypothyroid or euthyroid rats. Hypothyroid rat hepatocytes were previously shown to display a potentiated 8-adrenergic stimulation of cyclic AMP accumulation and activation of glycogen phosphorylase (Mal...

The role of central α-adrenergic receptors on imipramine-induced antinociception as revealed by formalin test in rat

In this study, the effect of α-adrenoceptor agents on imipramine-induced antinociception was investigated using formalin test. Intraperitoneal (i.p.) administration of imipramine at different doses (10-80 mg/kg) induced antinociception in both phases of formalin test. In addition, intracerebroventricular (i.c.v.) injection of imipramine (1, 5, and 10 µg/rat) did not elicit any effect, although ...

Adrenergic Receptors

Neurons in the paraventricular nucleus (PVN) that project to the brainstem and spinal cord are important for autonomic regulation. The excitability of pre-autonomic PVN neurons is controlled by the noradrenergic input from the brainstem. In this study, we determined the role of " 2 adrenergic receptors in the regulation of excitatory and inhibitory synaptic inputs to spinally projecting PVN neu...

Adrenergic regulation of glycogenolysis in rat liver after cholestasis. Modulation of the balance between alpha 1 and beta 2 receptors.

The effects of extrahepatic cholestasis upon adrenergic regulation of glycogenolysis and upon the numbers of adrenoceptors in rat liver were studied using isolated hepatocytes and plasma membranes, respectively. A 60% decrease in the number of alpha 1 adrenoceptors (285 vs. 680 fmol/mg protein) and a simultaneous 2.7-fold increase in the number of beta adrenergic sites (67 vs. 25 fmol/mg protei...

Adrenergic receptors in coronary arteries.